用于實驗室、PET、CT、SPECT、光學、核磁環(huán)境中處于麻醉狀態(tài)下的大小鼠以及其他稍大動物的生理監(jiān)測和門控成像。

小動物監(jiān)護&門控系統(tǒng)系統(tǒng)用于麻醉大小鼠及較大動物生理狀態(tài)監(jiān)護，可以搭配核磁兼容裝置，核磁環(huán)境下監(jiān)護大小鼠心電、呼吸和體溫，模塊化設(shè)計使用更加簡單方便。該系統(tǒng)包括一個ERT模塊和一個ERT控制器，PC可顯示多個波形、測量值和趨勢。門控通過監(jiān)測動物的心電呼吸信號,將圖像采集與心臟和呼吸的特定時相相匹配，舍棄一些主動運動期間的信號采集，通過對運動的監(jiān)測來達到抑制運動偽影的效果，增強圖像質(zhì)量。

優(yōu)勢特點：

1. 可在CT、PET、SPECT、光學成像、正常實驗環(huán)境工作
2. PC實時顯示監(jiān)測生理參數(shù)波形及數(shù)值、門控點設(shè)置等信息
3. 模塊化設(shè)計，用戶根據(jù)需求選配，節(jié)約實驗成本
4. 可監(jiān)測呼吸心電體溫等參數(shù)
5. R波門控延遲可由用戶設(shè)置，呼吸門控寬度可由用戶設(shè)置
6. 可選配脈搏血氧、EtCO2、有創(chuàng)血壓、光纖測溫及通氣輔助等功能
7. 可搭配核磁兼容模塊，兼容MR環(huán)境，可在高磁場環(huán)境下工作

應(yīng)用領(lǐng)域：

小動物核磁兼容監(jiān)護&門控系統(tǒng)廣泛應(yīng)用于各種MR、MRI、CT、PET CT成像中，將圖像采集與心臟和呼吸的特定時相相匹配，舍棄一些主動運動期間的信號采集，通過對運動的監(jiān)測來達到抑制運動偽影的效果，增強圖像質(zhì)量。

圖為小鼠主動脈根部：9.4T垂直場；心電圖和呼吸門控；90秒圖像，無對比度

圖為西門子7.0Tterra科研臨床兩用磁共振， 安裝SAll動物門控掃描減少偽影和心電監(jiān)護

圖為門控有創(chuàng)血壓模塊監(jiān)測股動脈

圖為1030型在核磁環(huán)境下應(yīng)用于靈長類動物顱腦部的監(jiān)護門控

部分用戶名單：

型號規(guī)格：

參考文獻：

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9.Robinson, Gain et al. “Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats.” Molecular imaging and biology vol. 26,1 (2024): 179-187. doi:10.1007/s11307-023-01876-9
10.Zhao, Qiulong et al. “Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR.” Journal of ethnopharmacology vol. 323 (2024): 117703. doi:10.1016/j.jep.2024.117703
11.Hune, Theresa et al. “Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13 C-Pyruvate-d3.” Chemphyschem : a European journal of chemical physics and physical chemistry vol. 24,2 (2023): e202200615. doi:10.1002/cphc.202200615
12.Wunker, Claire et al. “Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model.” Journal of visualized experiments : JoVE ,191 10.3791/64544. 13 Jan. 2023, doi:10.3791/64544
13.Burns, Jennie M et al. “Dilation of the superior sagittal sinus detected in rat model of mild traumatic brain injury using 1?T magnetic resonance imaging.” Frontiers in neurology vol. 14 1045695. 26 Apr. 2023, doi:10.3389/fneur.2023.1045695
14.Jendritza, Patrick et al. “Multi-area recordings and optogenetics in the awake, behaving marmoset.” Nature communications vol. 14,1 577. 2 Feb. 2023, doi:10.1038/s41467-023-36217-5
Cabral, Joana et al. “Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI.” Nature communications vol. 14,1 375. 6 Feb. 2023, doi:10.1038/s41467-023-36025-x

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